Heat syndrome can be moxibustion or not which is a controversial topic for a long time, each point of view comes out repeatedly, this paper attempts to explore through the entropy theory and other relevant angles: its connotation points out that the system is always in an orderly to disorderly process of return. At the same time, the concept of negative entropy provided a scientific basis for keeping the system orderly (relative equilibrium steady state). Compared to the state of disease, it was suggested that the intervention of moxibustion therapy on heat syndrome could cause the heat dissipation and warming of the organism. Make the body obtain negative entropy, disease to the recovery, thus discussing the feasibility of moxibustion of heat syndrome. On this basis, the relationship between the quantity of moxibustion and the curative effect is analyzed at a further level, and the relationship between the quantity of moxibustion and the curative effect is also analyzed. In order to put forward a new angle of scientific quantification, the theoretical construction of “moxibustion with heat syndrome” was put forward.