Objective：To apply the traditional Chinese medicine inheritance support platform（V2.5） to study the medication and prescription formula of MengHe Medicine''s treatment of water-qi disease in "MengHe Medical Schools". Methods: The prescriptions for the treatment of water-qi disease in the " MengHe Medical Schools " were collected and organized. After standardization of data processing, the data was entered into the system platform, and a database was established. The frequency statistics and relation regulations of the traditional Chinese medicine inheritance platform software (V2.5) were used. Such data processing methods were used to analyze the commonly used drugs, combination rules, and core combinations of the prescriptions of the MengHe Medicine for the treatment of water-qi disease, and to explore the prescription patterns of their prescriptions. Results: A total of 97 prescriptions were included. The core medicines were wolfberry, orange peel, big-bellied skin, Alisma orientalis, Atractylodes macrocephala, winter melon seeds and mulberry white skin, 10 core prescriptions and 5 new prescription candidates. Conclusion: MengHe Medicine treating Water-qi disease selects sweet，spicy and warm drugs, treatment emphasis on qi and spleen, accelerating the operation and metabolism of water, combination of evil spirits and righting, providing a basis and guidance for clinical treatment.