经络的客观存在得到实验证实,但是关于经络形成机制的研究尚未见报道。在整合国内外相关实验成果的基础上,研究发现经络系统的主体 ——十二经脉与细胞迁移通道具有相似的形成机制。呼吸中吸气肌节律性收缩或四肢、躯干运动等使相应的经穴打开,进而使穴区肥大细胞(MC)胞膜上辣素受体-2(TPRV2)通道开通,介导Ca&lt;sup&gt;2+&lt;/sup&gt; 和Na&lt;sup&gt;+&lt;/sup&gt;内流,MC被激活。MC脱颗粒释放两种丝氨酸蛋白酶,分泌介质刺激成纤维细胞等使之合成、分泌两种基质金属蛋白酶原,该两种酶原被丝氨酸蛋白酶活化成酶。丝氨酸蛋白酶和基质金属蛋白酶共同作用,降解细胞外基质蛋白质,开辟出十二经脉通道。由此推测：经络是酶促反应形成的空间定位、时间稳定的细胞外基质通道。
According to the viewpoint of traditional Chinese medical science, meridians and collaterals are the channels of Qi-blood operations. The existence of meridians and collaterals had been proved by experiments, but the research of meridians and collaterals formation mechanism hasn’t been reported. After studied and integrated worldwide experiment results, researches found that as the main part of meridians and collaterals system, twelve-meridians have similar formation mechanism to cellular migration channels. Rhythmic contraction movements of respiration muscles or limb or trunk movements stimulate the relevant acupoints to open, thus, to open TPRV&lt;sub&gt;2&lt;/sub&gt; channel of mast cell (MC) membrane to mediate Ca&lt;sub&gt;&lt;sup&gt;2+&lt;/sup&gt;&lt;/sub&gt; and Na&lt;sub&gt;&lt;sup&gt;+&lt;/sup&gt;&lt;/sub&gt; immigrate to activate MC. Degranulation of mast cells releases two serine proteinases, secretion mediators trigger fibroblast and other cells to synthesis and secrete two matrix pro-metalloproteases, which are enzymized by these two serine proteinases. Extracellular matrix proteins are partially degraded by the synergistic effect of serine proteinases and matrix metalloproteases to create twelve-meridians channel. Research results indicate that meridians and collaterals are the positioned and time-stable extracellular matrix channels, created by enzymatic reactions.