Ethical review is an important means of risk control of clinical researches internationally. The starting time of medical ethics in various countries in the world is different, and the level and degree of development is uneven, but the construction of ethics review in the world today is moving towards the construction of regional ethics committee (EC). In the process of establishing regional EC in China, we are faced with challenges of exploring the mutual ethics recognition mechanism, continuing examination of supervision ethics and protecting the rights and interests of research subjects. This paper shared the exploration of the regional EC of Beijing municipal hospital based on the model of traditional Chinese medicine (TCM) medical association mode. In the process of establishing the regional EC of municipal TCM hospital, a working communication platform was built to achieve the ethical review and supervise the follow-up collaborative subjects, and to accept the ethical review entrustment of trusteeship hospitals, finally to gradually help the trusteeship hospital to improve their own ethical review system and level. This paper put forward that in the process of constructing regional EC in China. It is necessary to unify the ethical review standards, to form a reasonable working procedure and to improve the ethical review efficiency.