In view in the clinical application of Fresh Chinese medicine (FCM), the treatment effect of FCM on a variety of diseases is better than that of dry one. In order to facilitate the application of FCMto make it play a better role, it is urgent to develop and prepare fresh Chinese medicine decoction pieces (FCMDP) for clinical application. Therefore, this paper takes the common fresh drug Houttuynia cordata Thunb. as an example, compares the dosage of dried and fresh Houttuynia cordata Thunb. by the statistics reports in historical documents and modern studies, and analyzes the reasons for the differences in dosages, so as to provide some enlightenment for the future research on FCM, and to better inherit and carry forward the characteristics and advantages of FCM.