目的 实现实验性芤脉“脉变”前后的中医四诊合参信息数字化和量化，创建人体无创的失血、伤津模型。方法 对符合纳入标准随机选取的31例受试者，在安静端坐状态下，测量血压并使用四诊合参辅助诊疗仪采集中医四诊信息，然后嘱受试者做Valsalva动作，同时采集四诊信息。通过分析比较受试者数字化和量化的中医四诊合参诊断信息，评价模拟失血、伤津模型。结果 与自然状态相比，31例受试者，做Valsalva动作时脉力、弦紧度、血压降低（P < 0.01），脉率、变异系数（coefficient of variation，CV）、脉搏波传导速度（pulse wave velocity，PWV）升高（P < 0.01），Valsalva动作后舌质颜色加深（P < 0.01）。结论 本研究利用四诊合参辅助诊疗仪将Valsalva动作前和Valsalva动作时的中医四诊合参信息数字化、量化，对比建立了人体无创中医失血、伤津模型。
Objective This study was aimed to digitize and quantify the information of the four diagnostic records of Traditional Chinese medicine (TCM) before and after the experimental hollow pulse change, constructing a non-invasive model of blood loss and body fluid loss.Methods 31 subjects who were randomly selected according to the inclusion criteria were measured in a quiet sitting position, measuring blood pressure and collecting information on TCM four consultations with portable four-integration collateral auxiliary medical instrument. Afterwards, the subjects were asked to do the Valsalva action while collecting relevant information again. Through analysis and comparison of the digitized and quantified diagnostic information of the TCM four-diagnostic method combination, evaluate and simulate the non-invasive model of blood loss and body fluid loss.Results 31 subjects did the Valsalva action, compared with the normal state, pulse force, string tightness and blood pressure of them were decreased (P < 0.01). And pulse rate, coefficient of variation and PWV were increased obviously (P < 0.01). After the Valsalva action, tongue color was getting deeper compared with the normal state (P < 0.01). Conlusion It was concluded that the four-diagnosis and auxiliary medical treatment instrument was used to digitize and quantify the information of the four-integration of TCM before the Valsalva movement and in the Valsalva movement, and to establish a non-invasive TCM of blood loss and body fluid loss in this study.